Abstract
Gastrointestinal stromal tumor (GIST) is an uncommon gastrointestinal neoplasm with high rate of malignant transformation. The tumor is found mainly in the stomach and the small intestine, and the anorectum is an extremely rare anatomical location for this pathology. GIST is often discovered incidentally by a computerized tomography scan, endoscopy or during a laparotomy for other reasons. We describe a case of 64-year-old female with a mass in the anal canal presenting with tenesmus and difficulty defecation. Endoscopic ultrasonography and magnetic resonance imaging showed a mass at the rectum, externally compressing the vaginal wall. The patient was managed by a local excision which was preceded by an upfront therapy with imatinib. Histological examination showed proliferation of spindle cells stained with CD34 compatible with GIST. On post-operative follow-up visit, the patient did well with continuing imatinib therapy.
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