Abstract
Meningiomas in the frontoparietal lobe may cause anxiety disorders and panic attacks. While alprazolam is one of the most widely used medications for anxiety disorders, long-term use may result in adverse side effects (withdrawal and rebound effects). This case study aims to describe the efficacy of long-term alprazolam administration in patients with meningiomas for regulating anxiety disorders. Case report :The asymmetrical face is the primary concern of a 65-year-old female when she is anxious. The results of the physical assessment and laboratory tests are within normal ranges. However, The HARS procedure showed moderate anxiety, and the CT scan revealed a meningioma in the right frontoparietal lobe. To regulate patient anxiety disorders, doctors give alprazolam 0.5 mg per day single dose for 4 months and tapering off for 3 months. Conclusion: Long-term administration of alprazolam in these patients can reduce the patient's anxiety disorder without causing withdrawal or rebound effects. A low dosage of alprazolam, a mild level of anxiety illness, and a slow tapering off phase were factors that contributed to the effectiveness of alprazolam treatment to suppress anxiety symptoms in this situation.
Highlights
Kedokteran, Fakultas Kedokteran, Universitas Hang Tuah Surabaya, Jl
This case study aims to describe the efficacy of long-term alprazolam administration in patients with meningiomas for regulating anxiety disorders
The HARS procedure showed moderate anxiety, and the CT scan revealed a meningioma in the right frontoparietal lobe
Summary
Efektivitas Alprazolam Pada Pasien Meningioma gulasi gangguan kecemasan yang diderita pasien, dokter memberikan terapi alprazolam 0.5 mg per hari single dose selama 4 bulan dan tapering off selama 3 bulan. Kesimpulan: Pemberian alprazolam jangka panjang pada pasien tersebut dapat menekan gangguan kecemasan pasien tanpa menimbulkan efek withdrawl maupun rebound effect. Gejala yang berbeda ditemukan pada kasus meningioma, terutama yang menekan lobus frontal tidak menghasilkan gejala apa pun selain perubahan progresif pada kepribadian dan kecerdasan sampai massa tumor membesar secara signifikan, sehingga dikenal dengan istilah ―silent tumor‖ Hussain et al (2015). Disamping efektivitasnya yang sangat poten dan cepat untuk menanggulangi gangguan psikiatri, penggunaan alprazolam jangka panjang (lebih dari 2 – 4 minggu) memicu efek withdrawal dan abstinesia Louvet et al (2015). Hal tersebut memicu aktivitas kimiawi otak tanpa adanya hambatan fisiologis endogen, sehingga memicu gangguan yang mirip dengan kondisi sebelum menggunakan obat, yang dikenal dengan istilah abstinensia. Beberapa hal penting yang akan diungkap dalam laporan kasus ini adalah keefektifan penggunaan alprazolam jangka panjang untuk mereduksi gejala gangguan kecemasan penderita meningioma frontoparietal dextra
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