Abstract
BackgroundTacrolimus has been widely used for immunosuppressive therapy in solid organ transplantation (SOT) and allo-geneic stem cell transplantation (allo-SCT) over the past 2 decades. Pancreatitis caused by tacrolimus was rarely reported in kidney transplantation previously.Case presentationHere we presented a case of a 45-year-old male who underwent kidney transplantation and received immunosuppressive therapy of tacrolimus, on day + 67 after transplantation he developed acute pancreatitis with extremely high blood concentration of tacrolimus. We excluded other possible causes and speculated tacrolimus was the probable inducer of pancreatitis. After tacrolimus was discontinued and alternated with cyclosporine, he gradually recovered and was discharged home with no relapse.ConclusionTacrolimus can be a probable cause of pancreatitis after kidney transplantation. We recommended clinicians to be aware of the possibility of tacrolimus-induced pancreatitis during tacrolimus treatment.
Highlights
Tacrolimus has been widely used for immunosuppressive therapy in solid organ transplantation (SOT) and allo-geneic stem cell transplantation over the past 2 decades
Tacrolimus can be a probable cause of pancreatitis after kidney transplantation
We recommended clinicians to be aware of the possibility of tacrolimus-induced pancreatitis during tacrolimus treatment
Summary
Tacrolimus has been widely used for immunosuppressive therapy in solid organ transplantation (SOT) and allo-geneic stem cell transplantation (allo-SCT) over the past 2 decades. Conclusion: Tacrolimus can be a probable cause of pancreatitis after kidney transplantation. Background Drug-induced pancreatitis is an adverse effect associated with varies of drugs, more than one hundred drugs have been reported to be the probable causes of pancreatitis [1, 2].
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