Abstract
A Case Report: A 15 Year-Old-Female with Elevated C - Reactive Protein, Major Depression and Maltreatment in Early Childhood
Highlights
Ms S is a 15 year old female with refractory major depressive disorder
Studies are currently showing the relationship between C-reactive protein (CRP) and depression as well as the effects of C - reactive protein (CRP) on neurotransmitter pathway and the basal ganglia
This study further showed that increased concentrations of glutamate is connected to elevated CRP and the symptom of anhedonia
Summary
To consider treatment of antidepressant resistant patients to combine or substitute antidepressant medications with antiinflammatory medications. These metabolites are essential building blocks for the formation of mood neurotransmitters Based off these results, her medications were changed at her following appointment with the program Psychiatrist, and L-methylfolate 15 mg, a medical food, was added to the patient’s treatment regimen for depression with a plan to taper off Duloxetine and add Desvenlafaxine. Her medications were changed at her following appointment with the program Psychiatrist, and L-methylfolate 15 mg, a medical food, was added to the patient’s treatment regimen for depression with a plan to taper off Duloxetine and add Desvenlafaxine Her Aripiprazole was discontinued and Lurasidone 20 mg was started. The patient reported another selfharming episode that resulted in cuts on her inner thighs, and complained of having frequent, violent, suicidal thoughts Her medication regimen was changed to Duloxetine 50 mg, Lurasidone 20 mg, Desvenlafaxine 25 mg, and L-methylfolate 15 mg. She denies any recent selfharm or suicidal ideation, to date
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