Abstract

We present the case of a 54-year-old lady who presented to hospital with palpitations and was diagnosed with atrial fibrillation with rapid ventricular response. She was given intravenous metoprolol 5 mg initially followed by a further 5 mg and was commenced on bisoprolol 2.5 mg once daily. She reverted back to normal sinus rhythm and was referred for echocardiography following an episode of paroxysmal atrial fibrillation. The echocardiogram showed a large mobile atrial myxoma in the left atrium and mild-to-moderate mitral regurgitation with preserved left ventricular function. Her past medical history includes transsphenoidal surgery for acromegaly in 1979, followed by radiotherapy and partial thyroidectomy for goitre. Her chest radiograph was normal and blood results were unremarkable. She was accepted for inpatient transfer to a cardiothoracic centre for surgical removal of atrial myxoma. She underwent surgery with successful excision of the atrial myxoma, and biopsies confirmed the mass to be atrial myxoma. The surgery was complicated by the patient developing atrial fibrillation with fast ventricular response that was chemically cardioverted with an intravenous loading dose of amiodarone 300 mg over 2 hours followed by 900 mg infusion over 24 hours. She had follow-up in the outpatient clinic with cardiology and endocrine specialists for a year and no recurrence of myxoma was noted. Her blood tests including growth hormone and thyroid function tests were normal.

Highlights

  • Carney complex (CNC) is an autosomal genetic syndrome characterized by spotty pigmentation of the skin, endocrinopathy, and endocrine and nonendocrine tumours such as myxomas of the skin, heart, breast, and other sites [1]

  • We present the case of a 54-year-old lady who presented to hospital with palpitations and was diagnosed with atrial fibrillation with rapid ventricular response

  • We present the case of a 54-year-old female who presented to the emergency department (ED) with atrial fibrillation (AF) with rapid ventricular response

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Summary

Introduction

Carney complex (CNC) is an autosomal genetic syndrome characterized by spotty pigmentation of the skin, endocrinopathy, and endocrine and nonendocrine tumours such as myxomas of the skin, heart, breast, and other sites [1]. We present the case of a 54-year-old female who presented to the emergency department (ED) with atrial fibrillation (AF) with rapid ventricular response Her only past medical history consists of transsphenoidal surgery for acromegaly in 1979, followed by radiotherapy and partial thyroidectomy for goitre. The echocardiogram showed normal left ventricular ejection fraction >60%, mild left atrial dilatation, and a large left atrial mobile mass (5.6 cm × 3.0 cm in diameter), which was homogeneous and regular in appearance, adhered to the interatrial septum with no gradient of stenosis or signs of regurgitation (Figures 1, 2, 3) On physical examination, she had pigmented freckles, coarse facial features, and big hands suggestive of acromegaly. She remained stable on 25 mg of split-dose hydrocortisone when she was seen in the endocrine outpatient clinic

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10. Carney JA
13. Bertherat J
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