A Case of Terbinafine-Induced Subacute Cutaneous Lupus Erythematosus rapidly resolving with Upadacitinib.

Abstract

Drug-induced subacute cutaneous lupus erythematosus (SCLE) is a lupus-like cutaneous eruption without systemic features that results due to insult from a range of chemically diverse culprit drugs. In cases where remission is not achieved with drug discontinuation, treatment options generally involve those used to treat idiopathic SCLE, including topical or systemic corticosteroids, antimalarials and/or immunosuppressive drugs. Herein we present a case of drug-induced SCLE secondary to terbinafine with a prolonged course following drug cessation that did not respond to classical treatments, but demonstrated rapid and sustained improvement within 48 hours of upadacitinib treatment.