A case of symmetrical drug-related intertriginous and flexural exanthema caused by valacyclovir

Masataka Satoh,Toshiyuki Yamamoto

doi:10.7241/ourd.20142.52

Abstract

Introduction Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) has recently been separated from baboon syndrome and proposed as a unique type of drug eruption [1], which appears only on intertriginous or flexural folds and in gluteal areas in the absence of systemic involvement. Antibiotics including amoxicillin and cephalosporins are the most common drugs causing SDRIFE [2]. We report herein a case of SDRIFE showing symmetrical erythema predominantly on major flexural areas, rapidly developed after taking valacyclovir, which was suggested as a causative drug by skin patch test.

Highlights

Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) has recently been separated from baboon syndrome and proposed as a unique type of drug eruption [1], which appears only on intertriginous or flexural folds and in gluteal areas in the absence of systemic involvement
We report a case of SDRIFE showing symmetrical erythema predominantly on major flexural areas, rapidly developed after taking valacyclovir, which was suggested as a causative drug by skin patch test
[1], is an uncommon type of drug eruption. This condition is characterized by five clinical criteria: occurrence after exposure to systemic drugs, sharply-demarcated erythema of the buttocks and/or V-shaped erythema of the thighs, involvement of at least one other flexural fold, symmetry, and the absence of systemic symptoms

Summary

Introduction

Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) has recently been separated from baboon syndrome and proposed as a unique type of drug eruption [1], which appears only on intertriginous or flexural folds and in gluteal areas in the absence of systemic involvement. Cite this article: Satoh M, Yamamoto T. A case of symmetrical drug-related intertriginous and flexural exanthema caused by valacyclovir. Introduction Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) has recently been separated from baboon syndrome and proposed as a unique type of drug eruption [1], which appears only on intertriginous or flexural folds and in gluteal areas in the absence of systemic involvement.

Results

Conclusion