Abstract
BackgroundCervical cancer during pregnancy is rare. The management for stage IB3 during pregnancy remains unclear and challenging. We report a successful preserved pregnancy in a stage IB3 patient who was treated with neoadjuvant chemotherapy (NACT) plus radical surgery.Case presentationA 36-year-old pregnant woman was diagnosed with a 5-cm-diameter stage IB3 squamous cell carcinoma of the uterine cervix at 13 gestational weeks. The patient received 5 courses of systemic chemotherapy with carboplatin and paclitaxel every 3 weeks, followed by caesarean section and radical hysterectomy. Both the mother and infant are in good general condition.ConclusionThis case suggests that NACT plus radical surgery could be one method to maintain pregnancy in stage IB3 cervical cancer diagnosed as early as 13 gestational weeks.
Highlights
We here report a detailed case of stage IB3 cervical cancer diagnosed at 13 gestational weeks successfully treated with neoadjuvant chemotherapy (NACT) using carboplatin and paclitaxel followed by radical surgery during pregnancy
The current case suggests NACT using carboplatin and paclitaxel followed by radical surgery during pregnancy could be applied for the treatment of cervical cancer stage IB3 diagnosed in the first trimester of gestation for women who desire to preserve pregnancy
The management for stage IB3 cervical cancer during pregnancy is controversial, for which NACT or termination of pregnancy was recommended by INCIP if the diagnosis is made before 22 weeks’ gestation [2]
Summary
We here report a detailed case of stage IB3 cervical cancer diagnosed at 13 gestational weeks successfully treated with neoadjuvant chemotherapy (NACT) using carboplatin and paclitaxel followed by radical surgery during pregnancy. A caesarean section at 35 weeks’ gestation was performed 3 weeks after the last cycle of chemotherapy to allow both maternal and fetal bone marrow to recover, followed by radical hysterectomy and pelvic lymphadenectomy.
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