Abstract
Anwarul Islam1* and Joanne Becker2 Author Affiliations 1Clinical Associate Professor of Medicine, Division of Hematology/Oncology, Department of Medicine, Buffalo General Hospital, Buffalo, New York 14203, USA 2Associate Professor and Clinical Chief, Division of Laboratory Medicine, Department of Pathology and Laboratory Medicine, Medical Director, Blood Bank and Therapeutic Apheresis Unit, Roswell Park Cancer Center, Buffalo, New York 14203, USA Received: April 08, 2020 | Published: April 23, 2020 Corresponding author: Anwarul Islam, Clinical Associate Professor of Medicine, Division of Hematology/Oncology, Department of Medicine, Buffalo General Hospital, Buffalo, New York 14203, USA DOI: 10.26717/BJSTR.2020.27.004468
Highlights
Her 24 hr. urinary Bence Jones protein (BJP) was high at 32.6 (0.00-0.00) and urine immunofixation electrophoresis (IFE) revealed kappa BJP
We present a case whose serum protein electrophoresis revealed two spikes in gammaglobulins and immunofixation electrophoresis identified two protein components, one- IgA kappa only and one IgG kappa+lambda
Multiple myeloma is a group of plasma cell neoplasms which result in the production of a specific and unique monoclonal immunoglobulin (M-component)
Summary
Her 24 hr. urinary Bence Jones protein (BJP) was high at 32.6 (0.00-0.00) and urine IFE revealed kappa BJP. The majority of patients with multiple myeloma (monoclonal gammopathies) typically have a single clone of plasma cells, secreting a unique type of monoclonal protein, one heavy chain and one light chain. A simultaneous presence of monoclonal and polyclonal protein in the same case is rare.
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