Abstract
Syphilis is a sexually transmitted disease caused by Treponema pallidum. The signs and symptoms of syphilis vary depending on which of the four stages it presents. The primary stage of syphilis classically presents with a painless ulcer (chancre). We report a case of the extragenital chancre on the nipple which is examined from skin biopsy and immunohistochemistry. This case showed that it is important to identify the special site's pruritus erythema by pathology and serological examination.
Highlights
Syphilis is a common sexually transmitted or blood contracted, congenital transmission disease
Syphilis is a sexually transmitted disease caused by Treponema pallidum [1]. e primary-stage of syphilis is mainly characterized by painless ulcers, which occur mostly in the genitals, anus, oral cavity [2], lips, pharyngeal, and nipple-areola [3]. ere have been several reports of primary syphilis
2: Biopsy of the nipple showed that epidermal hyperplasia, cutaneous protrusion, a migration of small amount of inflammatory cells, an infiltration of large number of cells around the blood vessels of the dermis (a). e inflammatory cells in the dermis were majorly lymphocytes and plasma cells (b). (H-E staining, original magnification: (a) ×100; (b) ×400)
Summary
Syphilis is a common sexually transmitted or blood contracted, congenital transmission disease. It can be divided into primary syphilis, secondary syphilis, tertiary syphilis, and neurosyphilis. E diagnosis is based on the clinical manifestations and serological methods. We report a case of secondary syphilis with extragenital chancre on the nipple
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