Abstract
Sarcoidosis is a systemic granulomatous disease of unknown etiology that typically affects young adults. Diagnostic criteria for sarcoidosis include involvement of two or more of the following organ systems: 1) pulmonary infiltrates; 2) bilateral hilar adenopathy; and 3) skin and/or eye lesions. Musculoskeletal system is less commonly involved. For that reason potential presenting symptoms can vary and make the diagnosis very challenging; particularly if a patient has symptoms that mimic other conditions. Musculoskeletal involvement for example can mimic malignancy. The following case describes a patient with known history of primary metastatic mediastinal Germ Cell Tumor (GCT) with teratomatous elements who is diagnosed with sarcoidosis involving skeletal tissues.
Highlights
Sarcoidosis is a chronic inflammatory disease, characterized by noncaseating granulomas, which can affect any organ, but most commonly the lungs
The described patient was found to have multiple painless bone lesions on imaging studies related to his Germ Cell Tumor (GCT)
It is important to keep in mind that at the time the patient already had an established diagnosis of Sarcoidosis
Summary
Sarcoidosis is a chronic inflammatory disease, characterized by noncaseating granulomas, which can affect any organ, but most commonly the lungs. 5 of osseous involvement in Sarcoidosis has been increasing due to improved imaging techniques such as MRI and PET, true incidence rate have been difficult to assess for several reasons. Because when symptoms of bone pain do exist, their diagnosis is obscured by classic musculoskeletal clinical manifestations of Sarcoidosis including arthralgias, sarcoid arthritis and sarcoid myopathies.
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