Abstract
A 37 year-old man presented with the left-sided hypohidrosis over the upper portion of the body. He had anisocoria, generalized areflexia and absence of light-reflex on the right side. Thermal sweating was defective over the left side of the upper body and on the right leg. Acetylcholine focal sweating on the forearm and palmar sweating were markedly reduced on the left side. After immersion of the hands in the hot water (42 °C, 10 min), the right hand showed apparent wrinkling of the palm skin, whereas the left hand showed no wrinkling. Sympathetic flow response was almost symmetric. These investigations support the notion that sympathetic nerve function may exert a crucial role in the production of hand skin wrinkling. However, which of the multiple sympathetic functions is relevant to the hand wrinkling remained unclear.
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