Abstract
A Case of Rhabdomyolysis and Polyarticular Inflammatory Arthritis May be the Initial Presentation of Chronic Myelogenous Leukemia (CML)
Highlights
A 28 year old male with no significant past medical history presents to the emergency department with severe bilateral thigh pain for 4 days after engaging on mild aerobic activity
Our 28-year-old male with acute rhabdomyolysis and inflammatory polyarthritis is the first case described as initial presentation of De novo Chronic Meylogenous Leukemia (CML)
Because tyrosine kinases participate in diverse signaling pathways, these enzymes might participate as well in the regulation of signal transduction in smooth muscle causing muscle spasm and potentially a leak of creatine kinase in CML patients [12]. It is unclear if the continuous activation of tyrosine kinase by the BCR-Abl plays an important role in the pathogenesis of patients with acute rhabdomyolysis
Summary
A 28 year old male with no significant past medical history presents to the emergency department with severe bilateral thigh pain for 4 days after engaging on mild aerobic activity His thigh pain was restricting his ambulation and daily life activities, was better at rest, worse with any movement especially getting up from sitting to standing position and when climbing stairs, and did not improved with 2 tablets of ibuprofen. He noted a dark brown discoloration of the urine and bilateral swelling of the hands and knees 1 day prior admission. The patient’s blood pressure was 160/100, his heart rate was 105; other vitals and oxygen saturation were normal He had bilateral hand swelling and synovitis, and mild bilateral knee swelling with synovitis.
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