Abstract
Inhibition of angiogenesis is a target in the treatment of a variety of malignancies. Sorafenib is an oral inhibitor of multiple tyrosine kinases involved in tumor angiogenesis. A related case of ophthalmologic toxicity has been reported with another vascular endothelial growth factor receptor inhibitor, sunitinib. We report the first case of retinal tear possibly associated with sorafenib.
Highlights
We report the first case of retinal tear possibly associated with sorafenib
Sorafenib is on oral inhibitor of multiple tyrosine kinases, including vascular endothelial growth factor receptors (VEGFR), approved for the treatment of unresectable hepatocellular carcinoma (HCC) and advanced renal cell carcinoma [1]
Systemic VEGF inhibitors are associated with toxicities that can lead to visual symptoms, such as systemic hypertension, which may result in hypertensive retinopathy [3]
Summary
Sorafenib is on oral inhibitor of multiple tyrosine kinases, including vascular endothelial growth factor receptors (VEGFR), approved for the treatment of unresectable hepatocellular carcinoma (HCC) and advanced renal cell carcinoma [1]. The most common adverse events noted with sorafenib include hand–foot syndrome, rash, diarrhea, fatigue, and hypertension [2]. We report the first case of retinal tear possibly associated with sorafenib
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