Abstract
We report a 9-year-old Japanese girl who presented with muscle weakness and elevated serum levels of muscle-derived enzymes following mycoplasma infection. Rhabdomyolysis or myositis was suggested by magnetic resonance imaging and repeated four times within 4 years. Each episode developed following respiratory infection and spontaneously recovered. The diagnosis of Sjogren’s syndrome was made by decreased salivary secretion, MR sialography, lip biopsy, and positive anti-SSA/Ro antibody. Given the rarity of rhabdomyolysis/myositis, recurrent episode could be induced by infectious disease on the basis of underlying Sjogren’s syndrome. Conclusion: Sjogren’s syndrome should be considered as an underlying disease of recurrent infection-induced rhabdomyolysis/ myositis.
Highlights
The diagnosis of rabdomyolysis or myositis is often challenging in pediatric clinical setting because of various pathogenesis such as drugs, infections, autoimmunity, and metabolic diseases [1]
We report a 9-year-old Japanese girl who presented with muscle weakness and elevated serum levels of muscle-derived enzymes following mycoplasma infection
We reported a case of recurrent episodes of muscle weakness associated with elevation of serum musclederived enzyme levels
Summary
The diagnosis of rabdomyolysis or myositis is often challenging in pediatric clinical setting because of various pathogenesis such as drugs, infections, autoimmunity, and metabolic diseases [1]. Sjögren’s syndrome (SS), an autoimmune disorder primarily affecting exocrine gland, is often complicated by extra glandular involvement in both adults and children [2,3]. Complication of rabdomyolysis/myositis has been reported in adult SS [4,5,6], to our knowledge, there has been no report of the complication in childhood SS. Japanese girl with primary SS complicated by recurrent rabdomyolysis/myositis in association with infections
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