Abstract
BackgroundUnlike infections with mycobacteria, reports of unusual viral infections in interferon-gamma-receptor (IFNγR) deficient patients are scarce. Therefore, discussion about increased susceptibility to viral infections in these patients is ongoing.Case presentationWe describe a 51-year-old male with dominant partial interferon-gamma-receptor-1 (IFNγR1)-deficiency and recurrent Herpes simplex 2 meningoencephalitis as well as other viral reactivations since childhood.ConclusionsThis case further confirms an enhanced risk for viral disease in IFNγR-deficient patients and a role of interferon gamma for human antiviral defense.
Highlights
Unlike infections with mycobacteria, reports of unusual viral infections in interferon-gamma-receptor (IFNγR) deficient patients are scarce
Increased susceptibility to mycobacterial infection is the main feature of IFNγR deficiency [5]
At age 31, the patient suffered from severe chickenpox with a generalized pronounced vesicular rash and had another episode of varicella zoster virus (VZV) pneumonia requiring hospital admission at the same time as his son fell ill with chickenpox
Summary
Reports of unusual viral infections in interferon-gamma-receptor (IFNγR) deficient patients are scarce. We describe an IFNγR deficient patient with severe and recurrent infections with herpes viruses. HSV infection can have a severe clinical course causing neurologic damage [13, 15]. (2020) 7:14 patients with IFNγR-deficiency can successfully cope with such infections.
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