A case of pure foamy gland carcinoma of prostate on needle core biopsy

Abstract

Pure foamy gland carcinoma in prostate needle biopsy is seldom encountered. Majority of the prostatic carcinoma cases are acinar type adenocarcinoma. The features of classic acinar adenocarcinoma like large nuclei, prominent nucleoli and infiltrative pattern are not seen in most of the cases of foamy gland carcinoma. Foamy gland carcinoma (FGC) is composed of cells with characteristic abundant foamy cytoplasm and low N:C ratio. These low-grade FGC can mimic benign prostatic glands and thus serve as a diagnostic challenge. We here report a case of pure foamy gland variant of adenocarcinoma diagnosed on TRUS biopsy.