Abstract
A 69-year-old female was found to have an abnormal shadow in the right middle lobe during examination for operation for cecal cancer. Ten months later, she was admitted to our hospital because of enlargement of the shadow and development of macroglobulinemia. Transbronchial lung biopsy and elevated IgM in BALF (IgM/Alb was 2.75 times that in serum evidently suggested pulmonary malignant lymphoma. CHOP therapy was not effective, and resection of the mass was attempted but was not feasible because of extension of the lesion into the upper and lower lobes. The biopsy specimen obtained during surgery disclosed malignant lymphoma, diffuse small cell type (IgM kappa type, B-cell). Radiation therapy was effective with complete resolution of the shadow. In this case, transbronchial lung biopsy and BAL were useful in the preoperative diagnosis of pulmonary malignant lymphoma.
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