A case of pterygium-like proliferation containing postoperative limbal dermoid remnants: a clinicopathological study

Mizuho Mitamura,Susumu Ishida,Satoru Kase,Takeshi Ohguchi

doi:10.1186/s12886-020-01767-5

Mizuho Mitamura, Susumu Ishida + Show 2 more

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https://doi.org/10.1186/s12886-020-01767-5

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Abstract

BackgroundThis study reports a case of pterygium-like proliferation containing postoperative limbal dermoid remnants and its clinicopathological features.Case presentationA 79-year-old Japanese woman, with a history of congenital limbal dermoid resection at age 12, presented with a pterygium-like tissue growth in the left eye. Its temporal location and marked thickness with abundant fatty droplets were atypical of primary pterygium. We performed pterygium surgery and ocular surface reconstruction. Pathological findings included squamous metaplasia, neovessels, and elastic degeneration, as well as prominent subepithelial and stromal accumulation of collagen fibers, adipose tissue formation, and presence of a peripheral nerve corresponded with the frequent findings of limbal dermoid. Ki67, a marker for cell proliferation, was immunopositive in pterygial epithelial cells and neovascular endothelial cells, but not in dermoid components.ConclusionsAlthough the pathological finding of degenerative elastic fibers indicated the common feature of ultraviolet-induced pterygium, clinical appearances were atypical possibly due to modification with dermoid remnants.

Highlights

This study reports a case of pterygium-like proliferation containing postoperative limbal dermoid remnants and its clinicopathological features.Case presentation: A 79-year-old Japanese woman, with a history of congenital limbal dermoid resection at age 12, presented with a pterygium-like tissue growth in the left eye
Conclusions: the pathological finding of degenerative elastic fibers indicated the common feature of ultraviolet-induced pterygium, clinical appearances were atypical possibly due to modification with dermoid remnants
We demonstrated that proliferation activity was higher in pterygial epithelial cells than in normal conjunctival epithelial cells [2]

Summary

Introduction

This study reports a case of pterygium-like proliferation containing postoperative limbal dermoid remnants and its clinicopathological features.Case presentation: A 79-year-old Japanese woman, with a history of congenital limbal dermoid resection at age 12, presented with a pterygium-like tissue growth in the left eye. Conclusions: the pathological finding of degenerative elastic fibers indicated the common feature of ultraviolet-induced pterygium, clinical appearances were atypical possibly due to modification with dermoid remnants. * Correspondence: kaseron@med.hokudai.ac.jp 1Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo 060-8638, Japan Full list of author information is available at the end of the article the stromal tissue of primary pterygium [2], is widely known to be correlated with long-lasting ultraviolet exposure.

Results

Conclusion