Abstract
2 Signet ring cell carcinoma (SRCC) is a unique subtype of adenocarcinoma that is characterized by abundant intracellular mucin accumulation. SRCC can arise in various organs, including stomach, colon, breast, bladder, and prostate. SRCC can also arise as a primary lung tumor, but its incidence is low, ranging from 0.14% to 1.9% in the reported series. Therefore, SRCC in the lung is generally believed to be metastatic. But, recent several immunohistochemical studies have demonstrated that thyroid transcription factor-1 (TTF-1), cytokeratins 7 and 20 are specific markers for SRCC arising in the lung. We report a case of pulmonary SRCC with immunohistochemical characterization in a 54-year-old male. Chest X-ray and chest computed tomography (CT) scan showed a homogeneous mass, approximately 3 cm in diameter and subcarinal lymphadenopathy of left perihilar region. The tumor cells were mainly composed of signet-ring cells and strongly demonstrated cytokeratins (7+/20-). The investigations of whole body failed to reveal any other tumor. On the basis of immunohistochemical studies, we concluded that the tumor was SRCC arising in the lung.(Korean J Med 69:S830-S834, 2005)
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