Abstract
A case of primary malignant melanoma of the esophagus is reported. A 69-year-old woman was admitted to the hospital because of dysphagia. Barium meal study revealed elevated lesions in the middle thoracic esophagus. Endoscopic examination of the esophgus revealed four blackish elevated tumors and esophageal melanosis. Biopsy findings indicated malignant melanoma. Thoracic esophagectomy combined with cervical and mediastinal lymphoadenectomy was performed. The resected specimen included four localized blackish tumors, one of which was pedunculated and another one of which was located in the esophageal melanosis. The #107 and left #104 lymph nodes showed blackish swelling. Histological examination demonstrated primary malignant melanoma with junctional activity in pathological stage IV which was shown by #104 metastatic lymph node. Electron microscopy revealed tumor cells containing melanosomes. The DNA patterns of the esophageal tumors and #104 lymphnode were aneuploid. The patient received postoperative irradiation therapy, but died of lung metastasis 35 months after the surgery.
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