A Case of Primary Breast Diffuse Large B-Cell Lymphoma Treated with Chemotherapy Followed by Elective Field Radiation Therapy: A Brief Treatment Pattern Review from a Radiation Oncologist's Point of View.

So Hyun Ahn,Seok Ho Lee,Jae Hoon Lee,Jinho Choi,Kyu Chan Lee,Seung Heon Lee,Sang Hui Park,Kihoon Sung,Junshik Hong

doi:10.1155/2015/907978

Abstract

We here report a case of primary breast lymphoma (PBL). A 44-year-old woman presented with a painless mass in the right breast. Fine needle aspiration cytology and excisional biopsy were performed. Excisional biopsy revealed low grade lymphoma, which was subsequently confirmed with histopathology and diagnosed as diffuse large B-cell lymphoma (DLBCL). A chest computed tomography scan revealed a 3.5 cm sized breast mass with skin thickening and a small sized lymphadenopathy in the ipsilateral axilla. Radiation therapy including the right whole breast and ipsilateral axilla and supraclavicular lymph node was performed after the patient received four courses of R-CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone plus rituximab) chemotherapy. At the follow-up period of 42 months, the patient is surviving with no evidence of disease. No morbidities occurred in this patient during the follow-up period. We also briefly review the current practice pattern in PBL patients with DLBCL.

Highlights

Primary breast lymphoma (PBL) is a rare tumor that originates from lymph tissues
The incidence of PBL in all non-Hodgkin’s lymphoma (NHL) cases is less than 1%
We briefly reviewed the role of surgery, CTx, and radiation therapy (RT) in PBL patients with diffuse large Bcell lymphoma (DLBCL) as follows

Summary

Introduction

Primary breast lymphoma (PBL) is a rare tumor that originates from lymph tissues. The reported incidence is 0.04– 0.5% of malignant breast tumors [1]. The incidence of PBL in all non-Hodgkin’s lymphoma (NHL) cases is less than 1%. The most common histology in PBL was diffuse large Bcell lymphoma (DLBCL) [2]. PBL may behave in a similar clinical and radiological presentation as breast carcinoma, treatment modalities and outcomes differ. The use of radiation therapy (RT) and/or chemotherapy (CTx) differs in the literature, combined therapy with surgery, CTx, and involved field radiation therapy (IFRT) or elective field radiation therapy (EFRT) is currently considered to be the standard treatment approach for PBL patients with DLBCL [2, 3]

Results

Discussion

Conclusion