Abstract
A case of 44-year-old female with post-transfusion purpura which was first described as a severe megakaryocytic thrombocytopenic purpura by Schulman in 1961 was reported. The patient who experienced six times pregnancies, had not taken any drugs and not previously received blood transfusion until present time in her medical history. By the reason of the existence of anemia due to myoma uteri, she received the amounts of 1, 000ml of blood transfusion at the period of five days. One hour after the final blood transfusion, nasal and gingival bleeding and generalized purpura developed.The laboratory examination revealed severe thrombocytopenia, low complement hemolytic activity and antiplatelet isoantibody by the method of complement fixation and agglutination.It is interested that anti HL-A 9 antibody was detected in her serum. After 25 hospital days, the thrombocytopenic purpura disappeared and now she is healthy with a normal platelet count.The relation between antiplatelet isoantibody and histocompatible antigen, and the mechanism of the destruction of platelet by antibody and complement was discussed.
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