Abstract
A case of pemphigus foliaceus and pustular psoriasis with a brief review of literature
Highlights
Pemphigus foliaceus (PF) is an autoimmune bullous disease (AIBD) which is presented by superficial flaccid blisters, erosions, scales and crusts on the seborrheic areas of the face and trunk without mucosal involvement [1]
Psoriasis and AIBD are classified as different diseases, PF coexistent with psoriasis vulgaris has been reported in a few cases [3], but association with pustular psoriasis has been very rare [4,5]
Our case initially had only bullous lesions which clinically and pathologically were diagnosed as PF but after decreasing the dosage of corticosteroid, she showed annular erythema and pustules with systemic symptoms, so the most probable diagnosis was PF superimposed by generalized pustular psoriasis (GPP)
Summary
Pemphigus foliaceus (PF) is an autoimmune bullous disease (AIBD) which is presented by superficial flaccid blisters, erosions, scales and crusts on the seborrheic areas of the face and trunk without mucosal involvement [1]. PF is characterized by granular layer acantholysis with acantholytic cells and intraepidermal deposition of Immunoglobulin G (IgG) and complement component 3 (C3) on immunofluorescent studies as a result of antibody production against desmoglein 1, a component of desmosome [2]. Psoriasis and AIBD are classified as different diseases, PF coexistent with psoriasis vulgaris has been reported in a few cases [3], but association with pustular psoriasis has been very rare [4,5]. Micro-environmental factors could be able to induce concurrent autoimmune phenomenon in an individual patient [3]. We report a case of PF and generalized pustular psoriasis (GPP)
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