Abstract
BackgroundVaricella-zoster virus (VZV) infection may induce central nervous system complications in HIV/AIDS patients. However, it is rare to have paraplegia caused by VZV infection but no herpes zoster clinically. Asymptomatic VZV infection in HIV/AIDS patient increased the difficulty of diagnosis.Case presentationWe reported a 41-year-old male AIDS patient with rare asymptomatic VZV infection-induced paraplegia after his anti-retroviral therapy initiation. MRI of the spinal cord showed the morphology of the thoracic spinal cord was irregular and locally inflated. The patient was confirmed as VZV induced thoracic myelomyelitis by using the cerebrospinal fluid for metagenomic next-generation sequencing (mNGS).ConclusionsmNGS may contribute to disease diagnosis for asymptomatic VZV infection-induced myelitis.
Highlights
Varicella-zoster virus (VZV) infection may induce central nervous system complications in human immunodeficiency virus (HIV)/Acquired Immune Deficiency Syndrome (AIDS) patients
*Correspondence: lianghao@gxmu.edu.cn †Zhiman Xie, Jingzhen Lai and Chuanyi Ning contributed to this work 3 Guangxi Collaborative Innovation Center for Biomedicine, Life Sciences Institute, Guangxi Medical University, No 22 Shuangyong Road, 530021 Nanning, Guangxi, China Full list of author information is available at the end of the article rare to have paraplegia caused by direct invasion of the spinal cord by VZV but no herpes zoster clinically in HIV-VZV coinfected patients
We present a rare case of myelitis due to VZV infection without VZVrelated clinical symptoms in AIDS patients who were diagnosed by cerebrospinal fluid (CSF) MAPMITM, a metagenomic next-generation sequencing technology
Summary
Varicella-zoster virus (VZV) infection may induce central nervous system complications in HIV/AIDS patients. Conclusions: mNGS may contribute to disease diagnosis for asymptomatic VZV infection-induced myelitis. The incidence of herpes zoster in antiretroviral therapy (ART)-naïve human immunodeficiency virus (HIV) infected patients can reach 9.4 % [2].
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