Abstract
Key Clinical MessagePalisaded neutrophilic granulomatous dermatitis is a cutaneous marker of a systemic disease. Clinicians’ goal should be directed toward determining an underlying condition. Even if the initial investigation is inconclusive, it may be necessary that some tests are repeated, since a serious underlying disease could be revealed in the course of time.
Highlights
Palisaded neutrophilic granulomatous dermatitis (PNGD) is an infrequent histopathological diagnosis usually associated with an underlying systemic disease,[1] such as connective tissue disease, rheumatoid arthritis, sarcoidosis, lymphoproliferative disorder, vasculitis, infection, and inflammatory bowel disease.[2,3]
A case of a patient with skin lesions that were histopathologically compatible with PNGD is presented, with subsequent development of chronic myelomonocytic leukemia (CMML)
It has been suggested that the granulomas may represent a nonspecific immunological response possibly related to the underlying disease.[10]
Summary
A case of palisaded neutrophilic granulomatous dermatitis with subsequent development of chronic myelomonocytic leukemia. Aikaterini Kyriakou1 | Aikaterini Patsatsi1 | Vassilios Papadopoulos2 | Anna Kioumi2 | Ioannis Efstratiou3 | Elizabeth Lazaridou[1]. 12nd Department of Dermatology and Venereology, General Hospital “Papageorgiou”, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece 2Hematology Department, General Hospital “Papageorgiou”, Thessaloniki, Greece 3Pathology Department, General Hospital “Papageorgiou”, Thessaloniki, Greece. Key Clinical Message Palisaded neutrophilic granulomatous dermatitis is a cutaneous marker of a systemic disease. Clinicians’ goal should be directed toward determining an underlying condition. Even if the initial investigation is inconclusive, it may be necessary that some tests are repeated, since a serious underlying disease could be revealed in the course of time. KEYWORDS connective tissue, lymphoproliferative, rheumatoid arthritis, sarcoidosis
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