Abstract
BackgroundThe aims of this report were to describe a case of ovarian adenosquamous carcinoma and to systematically review the pertinent literature.MethodsWe describe a case in which a 57-year-old woman had stage IC ovarian cancer histologically diagnosed as adenosquamous carcinoma. We also systematically reviewed the literature using the PubMed database.Case PresentationPreoperative computed tomography and magnetic resonance imaging showed a tumor measuring 14 cm in diameter and containing solid areas. Tumor marker levels were as follows: CA125, 42.6 U/mL; CA 19–9, 134.1 U/mL; CEA, 0.9 ng/mL; and SCC, 1.6 ng/mL. The patient underwent multiple surgeries including total abdominal hysterectomy, bilateral salpingo-oophorectomy, pelvic lymph node dissection, para-aortic lymph node biopsy, and total omentectomy. Based on the cytological features of the ascitic fluid, the tumor was diagnosed as a squamous cell carcinoma. Histological examination of an excised specimen showed the transition of an endometrioid adenocarcinoma to a squamous cell carcinoma. There was no evidence of any teratomas or endometriosis-related features. We considered the tumor to be an adenosquamous carcinoma, with the squamous cell carcinoma component arising from the endometrioid adenocarcinoma component. After surgery, the patient underwent 6 cycles of paclitaxel and carboplatin chemotherapy. There has been no recurrence to date, 66 months after the initial treatment.ResultsHistologically, the 8 adenosquamous carcinomas reported in the literature either arose from the mature cystic teratoma (4 cases) or endometriosis (3 cases) or were pure adenosquamous carcinomas (1 case). Our literature search uncovered no cases of ovarian adenosquamous carcinomas originating from endometrioid adenocarcinomas.ConclusionsThis is the first reported case of an adenosquamous carcinoma arising from an endometrioid adenocarcinoma. Because such tumors are rare, their standard management is unclear.
Highlights
The aims of this report were to describe a case of ovarian adenosquamous carcinoma and to systematically review the pertinent literature
This is the first reported case of an adenosquamous carcinoma arising from an endometrioid adenocarcinoma
We presented a rare case of an ovarian adenosquamous carcinoma in which the squamous cell carcinoma component originated from the endometrioid adenocarcinoma component
Summary
The aims of this report were to describe a case of ovarian adenosquamous carcinoma and to systematically review the pertinent literature. Conditions leading to the development of an adenosquamous carcinoma include malignant transformation of a preexisting ovarian teratoma [2, 3] and endometriosis [4]. We report a case of adenosquamous carcinoma that did not involve a preexisting teratoma or endometriosis. Based on the histopathological findings, we believe this tumor arose from the squamous metaplasia of an endometrioid adenocarcinoma. We describe this tumor and its histology in the context of previously reported cases obtained from a systematic review of the literature [1–7]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
