Abstract
A case of neonatal alloimmune neutropenia in premature infants with response to intravenous immunoglobulins
Highlights
Neutropenia is defined as a decrease in the absolute number of circulating neutrophils
Neonatal alloimmune neutropenia (NAN) occurs when the mother produces antibodies to an antigen of foetal neutrophils, which is inherited from the father and non-existent in the maternal neutrophils
The parents’ blood count was normal, and the diagnosis was confirmed by the study of maternal antibodies
Summary
Neutropenia is defined as a decrease in the absolute number of circulating neutrophils. Neonatal alloimmune neutropenia (NAN) occurs when the mother produces antibodies to an antigen of foetal neutrophils, which is inherited from the father and non-existent in the maternal neutrophils. These maternal alloantibodies are transfused into the foetus, destroying its circulating neutrophils and causing neutropenia. The neutropenia persisted, and so treatment was initiated with granulocyte-colony stimulating factor at 10 μg/kg/day (SC).
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