Abstract
In rats, water-immersion restraint stress is a model of experimental ulceration. We encountered a case in which multiple hemorrhagic gastric ulcers formed in the stomach in a setting similar to water-immersion restraint stress. The patient was a 54-year-old man who was found wet on a riverbank and transported by ambulance. Because of hypothermia and renal failure, hemodialysis was performed. Tarry stools were noted and endoscopy revealed the presence of multiple hemorrhagic gastric ulcers; thus, hemostasis was performed end oscopically. During the course, pseudo membranous colitis also developed and was ameliorated with vancomycin. Further, the renal failure and gastric ulcers improved, and the patient was discharged from hospital 25 days later. The reason why he survived more than 2 weeks was the hot summer season and he was not soaked in the river water throughout.
Highlights
There are many kind of stress causes of experimental ulceration
In ulceration by water-immersion restraint stress, mucosal damage begins to occur from the second hour, and fairly obvious stress ulceration occurs in 7 hours
The reason why ulcers occur in the gastric corpus of the fundic gland region but not in the pyloric gland region is attributed to the difference in the structure of capillaries between the fundic gland and pyloric gland regions
Summary
There are many kind of stress causes of experimental ulceration. Water-immersion restraint stress is a famous one of them. Water-immersion restraint stress is a model of experimental ulceration. This is a well-known method involving immersion of limbs in water for a long time to produce the stress response, i.e., ulceration. Stress ulcers are produced spotted or linear ulcers that occur only in the gastric corpus.
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