A case of Ménétrier's disease improved by eradication of Helicobacter pylori infection

Abstract

We reported a case of Ménétrier's disease associated with hypoproteinemia and enlargement of the gastric folds, which was successfully treated by eradication of Helicobacter pylori (H. p.) infection. A 47-year-old man developed giant fold gastritis associated with H. p. colonization and hypoproteinemia. Histological findings showed focal foveolar hyperplasia in the mucosa of the gastric body. He was treated with 600mg of clarithromycin (200mg three times a day) , 40mg of omeprazole (20mg twice a day) , 1,500mg of amoxicilln (500mg three times a day) for 14 consecutive days. After starting the treatment, the serum albumin and IgG levels increased. The treatment resulted in eradication of H. p. infection and the normalization of giant folds and the mucosal histological findings of the stomach. The serum albumin and IgG levels returned normal within 12 weeks and have remained normal since then. This case suggests both that eradication of H. p. infection is an effective therapy for Ménétrier's disease, and that H. p. infection plays an some etiological role in this disease through the improvement of the disease by eradication of H. p. infection.