Abstract
Megaloblastic anemias are a group of hematologic disorders in which abnormal DNA synthesis causes blood and bone marrow disorders. This type of anemias occurs as a result of folic acid deficiency or impaired vitamin B12 absorption. The prevalence of this type of anemia is highly variable worldwide and megaloblastic anemia caused by lack of vitamin B12 (cyanocobalamin) is rare during pregnancy [1]. In this case report, we report follow-ups conducted for a pregnant 33-year-old woman, G2, P1, with a history of previous natural childbirth who attended Kamali Hospital due to labor pain associated with severe thrombocytopenia. Although this woman was injected 10 units of PLT and also vitamin B12 (cyanocobalamin), folic acid and corticosteroids in the course of treatment, her platelet level has not yet returned to normal levels after 6 months and she is still being treated.
Highlights
After anemia, thrombocytopenia is the most common pregnancy disorder among blood disorders and occurs in 10% of pregnancies [2]
Gestational thrombocytopenia is defined as platelet count less than 150,000 per microliter [4]
Megaloblastic anemias are one of the causes of pancytopenias, a group of hematologic disorders in which blood and bone marrow disorders are caused by abnormal DNA synthesis [9]. This type of anemias occurs as a result of folic acid deficiency or impaired absorption of vitamin B12 caused by severe Addison’s anemia, complete or partial resection of stomach, resection of the ileum and the overgrowth of bacteria in the intestines and Crohn’s disease [1]
Summary
Thrombocytopenia is the most common pregnancy disorder among blood disorders and occurs in 10% of pregnancies [2]. Its prevalence throughout the world varies greatly and megaloblastic anemia caused by vitamin B12 deficiency (cyanocobalamin) is very rare during pregnancy This type of anemias causes curable anemias and pancytopenias; as a result its diagnosis and treatment are cost effective for patients and the society [10]. These diseases are diagnosed by low plasma folic acid levels (the first biochemical sign), hyper pigmentation of neutrophils (the first morphologic sign), significant increased Mean Corpuscular Volume (MCV), megaloblastic erythropoiesis in the bone marrow; there may be a slight anemia or vitamin B12 deficiency in pernicious anemia with neurological disturbances with normal MCV [11].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
