Abstract
Lymphomatoid granulomatosis (LYG) is a rare B-cell lymphoproliferative disorder that involves the skin in approximately 50% of cases. We describe a patient with LYG who first presented with cutaneous lesions. His skin biopsy failed to show large B-cell lymphocytes positive for Epstein-Barr virus (EBV)-encoded RNA in situ hybridization (EBER-ISH), highlighting the diagnostic challenges that dermatologists may face when encountering cutaneous LYG.
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