Abstract
We reported a case of lupoid hepatitis with pancytopenia which was successfully managed by splenectomy. A housewife, aged 41, was admitted for splenomegaly accompanied with left hypochondriac pain. Laboratory data showed pancytopenia, γ-globulinemia, slight liver dysfunction and autoantibody-positive. The patient was treated with prednisolone under a suspicion of autoimmune disease, and splenectomy was performed later on because of persistant severe left hypochondriac pain due to splenomegaly. Histological findings of the resected specimen liver indicated chronic hepatitis and those of the spleen indicated remarkably developed lymphoid follicules accompanying by no developed sinus nor onionskin lesion. Pancytopenia was improved and the titer of antinucler antibody decreased after operation. One month after operation, LE cell test turned to positive with impaired liver function so that she has been diagnosed as lupoid hepatitis.
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