A case of lipoprotein glomerulopathy and a literature review of the subject

Abstract

To improve the understanding of lipoprotein glomerulopathy, the clinical data of a single case of lipoprotein glomerulopathy, diagnosed at the Second Xiangya Hospital, Central South University in June 2011, were retrospectively analyzed. The analysis included clinical manifestation, laboratory results, and pathological information on kidney biopsy. Nephrotic syndrome was seen as the major clinical feature in this patient. Levels of serum apoE and apoB were increased. Obvious expansion of glomerular capillary cavities, filled with a weakly stained thrombus-like substance, were observed. ApoE immunohistochemical staining showed positive staining in capillary luminal contents. Transmission electron microscopy revealed capillary lumina occluded by various foaming lipid depositions in clustered or layered arrangement. There were no special symptoms nor obvious abnormal laboratory results of the LPG patient. Diagnosis of LPG should be based on clinical manifestations and renal biopsy. Characteristic pathological performance plays an important role in the diagnosis of lipoprotein glomerulopathy.