Abstract
Blue toe syndrome (BTS) is a condition characterized by the blue or violaceous discoloration of one or more toes as a result of tissue ischemia. First described in 1976 in a report of 31 patients who presented with cyanotic toes secondary to embolic phenomena, it has since been linked with several different diseases including embolic, thrombotic, infectious and vasoconstrictive disorders.1, 2 Three fundamental mechanisms are thought to underlie the alteration in skin color: diminished arterial perfusion, impaired venous outflow, and abnormal circulating blood.1 Here we report an unusual case of leukemia cutis secondary to chronic lymphocytic leukemia manifesting as blue toe syndrome in the absence of background cryoglobulinemia or cold agglutinin disease.
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