Abstract
Vulvar cancer is an uncommon tumor and represents 3%-5% of all female genital tract malignancies. Squamous cell carcinoma (SCC) is the most common carcinoma of the vulva. Distant metastasis of recurrent vulvar squamous cell carcinoma is rare and occurs late in the disease process. We report the first case of kidney metastasis from a vulvar squamous cell carcinoma in a 68-year-old Caucasian female. On initial presentation she was treated with radical vulvectomy, upper urethrectomy with bilateral inguinal and deep femoral lymph node dissection. She was staged as FIGO stage IVA and also received adjuvant chemo-radiation. She remained in remission for 24 months. Subsequently she was found to have a kidney tumor and underwent nephrectomy and was diagnosed with metastatic squamous cell carcinoma from the vulva to the kidney. In cases of recurrent vulvar carcinoma distant metastasis to the bones, breast, and brain is only rarely reported. Metastasis to kidneys from vulvar carcinoma is exceptionally rare with no reported cases in the literature. Renal metastasis should be considered in the differential diagnosis of kidney tumor in this group of women.
Highlights
Squamous cell carcinoma is the most common carcinoma of the vulva
Squamous cell carcinoma (SCC) of the vulva can spread via direct extension into adjacent structures, lymphatic embolization and hematogenous spread to distant sites [1]
CONCLUSION renal metastasis is rare, and has never been documented in a case of vulvar SCC, it should be considered in the differential diagnosis of flank pain and microscopic hematuria in women with a past history of vulvar carcinoma
Summary
Squamous cell carcinoma is the most common carcinoma of the vulva. Squamous cell carcinoma (SCC) of the vulva can spread via direct extension into adjacent structures, lymphatic embolization and hematogenous spread to distant sites [1]. Distant metastases in patients with primary SCC of the vulva are relatively rare and usually occur late in the disease process. In cases of recurrent vulvar carcinoma distant metastasis to bones, breast, and brain is rarely reported. Metastasis to kidneys from vulvar carcinoma is exceptionally rare with no reported cases in the literature. We present the first case of vulvar SCC with metastatic spread to the kidney
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