Abstract
A case of optic neuropathy induced by combined isoniazid and rifampin treatment is reported. The patient was a 61-year-old woman with a tuberculous abscess of the lung. She was treated with isoniazid (8.5–20 mg/kg/day, total dosage about 120 g) and rifampin (15 mg/kg/day, total dosage about 81 g) for approximately six months. At the end of this time, raised levels of glutamate oxalacetate transaminase and glutamate pyruvate transaminase were seen with peripheral sensory neuropathy. Rifampin was discontinued. Two months later, optic neuropathy also developed. Bilateral reduction of visual acuity, a central scotoma and abnormality of color vision were observed. Isoniazid was withdrawn and treatment by pyridoxine (vitamin B,) was initiated. Complete recovery of the optic neuropathy as well as the peripheral neuropathy was seen ten months after the withdrawal of isoniazid.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
