Abstract
Dengue is an important viral illness in endemic regions, with recent yearly outbreaks in Northern India. Acute kidney injury in dengue is seen usually in presence of shock and hemolysis. Direct immune mediated acute kidney injury is uncommon in dengue and usually presents late. We describe a young male with anuria and azotemia within first few days of illness, requiring hemodialysis. His low complement levels and response to corticosteroids suggest the possibility of immune complex mediated acute kidney injury, which may relate to severity of renal injury in dengue. It is important to suspect and recognize it early.
Highlights
Dengue fever, caused by dengue virus is currently the most important human viral mosquito-borne infection of public health significance
Proteinuria and abnormal urine sediment are the most common renal manifestations observed in patients with dengue fever
Acute tubular necrosis associated with interstitial edema and mononuclear cell infiltration may lead to acute kidney injury
Summary
Dengue fever, caused by dengue virus (an RNA flavivirus) is currently the most important human viral mosquito-borne infection of public health significance. Azotemia, glomerulonephritis, acute kidney injury and haemolytic uremic syndrome has been reported in dengue patients. All dengue hemorrhagic fever-induced acute kidney injury described cases have occurred in association with shock, haemolysis or rhabdomyolysis.
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