Abstract
Pemphigus is an autoimmune mucocutaneous bullous disease characterized by auto-antibodies against cell surface antigens of epidermal keratinocytes. Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are the major subtypes. Several other variants have been proposed, in-cluding pemphigus erythematosus, pemphigus vegetans, pemphigus herpetiformis (PH), and paraneoplastic pem-phigus. Deposition of IgG on epidermal keratinocyte cell surfaces and circulating anti-cell surface antibodies are characteristic in pemphigus. Cases involving IgA depo-sition on epidermal keratinocyte cell surfaces have been reported as IgA pemphigus. IgA pemphigus is divided into 4 subgroups based on clinical manifestation: subcorneal pustular dermatosis type, intraepidermal neutrophilic IgA dermatosis type, pemphigus foliaceus type, and pemphi-gus vulgaris type. Cases involving deposition of both IgG and IgA on keratinocyte cell surfaces have been reported (1–13). Some authors describe them as IgG/IgA pemphi-gus (1). Seventeen such cases have been reported so far, and heterogeneity of clinical features and target antigen has been detected in this group of pemphigus. CASe RePoRT
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