Abstract
Introduction: High-grade vulvar intraepithelial neoplasia (VIN3) is a common pathologic diagnosis. Usually, the lesions are associated with human papillomavirus (HPV), as demonstrated by block positivity on p16 staining. The lesions are not typically associated with amyloid deposition. It is even more rare to find amyloid spherules associated with high-grade vulvar dysplasia. The clinicopathologic significance of the amyloid spherules is unclear.
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