Abstract
A case of hepatic metastases from resected gastric leiomyoblastoma is reported. A 37-year-old woman was admitted to the hospital because of hematemesis, melena and general fatigue. She was preoperatively diagnosed as leiomyoblastoma by endoscopic examination, and underwent proximal gastrectomy. The excised tumor with an ulcer was 7.5×5.5×5.0 cm in size. Histological findings showed typical leiomyoblastoma with 50 mitotic figures/50 high power fields, and DNA ploidy pattern was diploid. The patient experienced recurrence and died of multiple hepatic metastases about two years later. Although leiomyoblastoma is recognized as benign in general, 20 (7.3%) out of 272 cases of gastric leiomyoblastoma reported in the Japanese literature are of malignant and their prognoses are poor. These 20 cases were clinicopathologically studied by dividing into benign and malignant groups, and some factors including age, location, maximum diameter of the tumor, and presence of ulcer appeared participate in the biological malignant potential.
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