Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease with multisystemic involvement. The commonly involved systems include mucocutaneous, musculoskeletal renal, and neuropsychiatry. SLE can also affect the central nervous and peripheral nervous systems which is associated with a worse prognosis. Neuropsychiatric manifestations of SLE (NPSLE) are common. They have been reported to present with various features. However, Guillain–Barré syndrome (GBS) has been rarely reported as a neuropsychiatric manifestation of SLE. The majority has reported GBS preceding the diagnosis of SLE. Here, we report the case of a 21-year-old female with a recent diagnosis of SLE who presented with a fulminant picture of GBS. She failed to respond to conventional therapy but responded well to cyclophosphamide.
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