Abstract
s / Journal of Reproductive Immunology 112 (2015) 121–140 137 ined how RVT modulates TRAIL-induced apoptosis of SiHa using Annexin–V staining. Results: SiHa was resistant to TRAIL-induced apoptosis. There wasn’t a significant difference between CaSki and SiHa regarding the expression of DR5 and survivin whilst pSTAT3 was expressed higher in SiHa compared to CaSki. Inhibition of STAT3 dramatically enhanced TRAIL-induced apoptosis of SiHa. Suppressing pSTAT3 expression, RVT significantly enhanced TRAIL-induced apoptosis of SiHa. Conclusion: STAT3 is suggested to play a central role in the resistance to TRAIL-induced apoptosis of cervical cancer. The therapeutics like RVT which can suppress STAT3 activation could be promising strategies for the treatment of cervical cancer. http://dx.doi.org/10.1016/j.jri.2015.09.050
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