A case of eosinophilic solid and cystic renal cell carcinoma-emerging entity

Abstract

Eosinophilic solid and cystic renal cell carcinoma (ESC RCC) is a recently described distinct and unique renal neoplasm that was originally described in female patients with tuberous sclerosis complex but now shown to occur mostly in a sporadic form with a female predominance. They result from somatic loss of TSC1 or TSC2 tumour suppressor genes. These tumours typically show a solid and cystic architecture, and the neoplastic cells are characterized by abundant granular eosinophilic cytoplasm with most showing a characteristic basophilic cytoplasmic stippling. The incidence is currently unknown because majority of cases were misdiagnosed or labelled as the more aggressive ‘unclassified renal cell carcinoma’ or ‘unclassified renal neoplasm with oncocytic or eosinophilic morphology’. We report a case of a twenty-three year old female with a solitary right renal mass. We review the literature and highlight the clinical and morphological features that distinguish this entity from other ‘eosinophilic’ Renal Cell Carcinomas.