Abstract
Introduction. Acromegaly is a chronic disease caused by chronic overproduction of growth hormone and IGF-1. This condition is manifested by a change in appearance, headache, and arthralgia. Systemic complications are diverse and include metabolic, cardiovascular, and osteoarticular complications, as well as a high risk of developing benign and malignant neoplasms. Acromegaly as a symptom complex being part of multiple endocrine neoplasia type 1 and type 4 (MEN1 and MEN4) occurs in 10 % of patients. The median age at acromegaly diagnosis in patients with MEN1 is 40 years of age; it is most commonly macroadenomas with invasive growth, mixed hormonal secretion, and poor response to treatment. Primary hyperparathyroidism occurs in 6.1 % of patients. The article provides a literature review of the main genetically determined diseases manifested in patients with acromegaly. A clinical case of endoscopic transsphenoidal resection of a pituitary adenoma in a patient with multiple endocrine neoplasia type 1 (MEN1) is also presented.
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