A case of diagnosis of diffuse large b-cell lymphoma with extranodular cervical disease

A A Grigorenko,V V Voytsekhovskiy,S N Roshchin

doi:10.36604/1998-5029-2021-80-84-90

A A Grigorenko, V V Voytsekhovskiy + Show 1 more

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https://doi.org/10.36604/1998-5029-2021-80-84-90

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Abstract

Aim. Demonstration of a case of diagnosing extranodal diffuse large B-cell lymphoma of rare localization – with a massive lesion of the cervix with spread to the body of the uterus and the anterior wall of the vagina.Results. The patient, born in 1991, considers herself ill since December 2020, when watery, bloody discharge from the genital tract first appeared. She went to the gynecologist at the place of residence; upon examination, a malignant neoplasm was suspected. For further examination and treatment, she was sent to the Amur Regional Oncological Dispensary, where a morphological and immunohistochemical study of the biopsy material was performed. In a histological specimen, there is a picture of lymphoma. Immunohistochemical study: tumor cells express CD10, CD20, BCL6, CD23. Tumor cells do not express CD5 (+ on small T-lymphocytes), BCL2 (+ on small T-lymphocytes), CD30, C-MYC, MUM1. When reacting with Ki-67, 90% of tumor cells are positive. The morphoimmunohistochemical picture is characteristic of diffuse large Bcell lymphoma from cells of germ cell centers.Conclusion. Diagnosis of extranodal lymphoma can be very difficult, and the leading role belongs to an experienced morphologist and the availability of modern diagnostics of the variant of lymphoma.

Highlights

For citation: Grigorenko A.A., Voytsekhovskiy V.V., Roshchin S.N
В данном случае имела место картина лимфомы, с характерной иммуногистохимической харрактеристикой: опухолевые клетки экспрессировали CD10, CD20, BCL6, CD23; не экспрессировали CD5(+на мелких Тлимфоцитах), BCL2(+на мелких Т-лимфоцитах), CD30, C-MYC, MUM1; при реакции с Ki-67 позитивными были 90% опухолевых клеток
Diagnosis of extranodal lymphoma can be very difficult, and the leading role belongs to an experienced morphologist and the availability of modern diagnostics of the variant of lymphoma

Summary

Introduction

For citation: Grigorenko A.A., Voytsekhovskiy V.V., Roshchin S.N. A case of diagnosis of diffuse large B-cell lymphoma with extranodular cervical disease. Случай диагностики диффузной В-крупноклеточной лимфомы с экстранодулярным поражением шейки матки // Бюллетень физиологии и патологии дыхания. При которых лимфатические узлы не увеличиваются, т.к. В качестве примера приводим случай диагностики экстранодальной ДВКЛ крайне редкой локализации – с массивным поражением шейки матки с распространением на тело матки и переднюю стенку влагалища. Образование растет преимущественно по передней и боковым стенкам, с распространением в параметрии с обеих сторон, больше справа, распространяется частично на тело матки и на переднюю стенку влагалища.

Results

Conclusion