A case of delayed primary-CNS post-transplant lymphoproliferative disorder in a patient with concurrent metastatic colorectal malignancy

Abstract

Introduction: Post-transplant lymphoproliferative disorders (PTLD) are a complication of immunosuppression following organ transplantation. Due to their heterogeneous presentation, diagnosis of PTLD can be challenging. Case Report: In this case report, we present a patient with metastatic colon cancer, with remote history of multivisceral organ transplant 20-years prior, who presented with altered mental status and was diagnosed with primary central nervous system PTLD. Conclusion: This case illustrates the importance of continued suspicion of PTLD long after transplantation in solid-organ transplant recipients, even in the setting of multiple comorbidities.