Abstract
1 Swiss Tropical and Public Health Institute, Basel, Switzerland, 2 University of Basel, Basel, Switzerland, 3 National Committee for Leprosy, Buruli Ulcer, Yaws and Leishmaniasis Control, Department of Disease Control, Ministry of Public Health, Yaounde, Cameroon, 4 Bankim District Hospital, Bankim, Cameroon, 5 Universitat Heidelberg, Heidelberg, Germany, 6 FAIRMED Africa Regional Office, Yaounde, Cameroon
Highlights
Spoligotyping and analysis using the SITVITWEB database revealed that the strain belonged to the ‘‘T-family’’ [6] of M. tuberculosis, a spoligotype of Lineage 4 which encompasses all strains that are difficult to classify into other spoligotype families
Buruli ulcer (BU) disease presents with a variety of clinical manifestations including nonulcerative forms such as movable subcutaneous nodules, plaques, and oedema, which may eventually progress to ulcerative lesions with characteristic undermined edges
It is believed that mycolactone, the macrolide toxin produced by M. ulcerans, largely contributes to the pathogenesis of BU disease [9]
Summary
Spoligotyping and analysis using the SITVITWEB database revealed that the strain belonged to the ‘‘T-family’’ [6] of M. tuberculosis, a spoligotype of Lineage 4 which encompasses all strains that are difficult to classify into other spoligotype families. Based on this laboratory diagnosis of an M. tuberculosis infection, the patient was reexamined 186 days after completion of the BU treatment. Given the laboratory results and the clinical presentation, the patient was retrospectively diagnosed as a case of cutaneous TB [7].
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