Abstract
COVID-19 is known to cause systemic disease with multiple organ dysfunctions. COVID-19 associated immune-mediated phenomena such as autoimmune haemolytic anaemia has been identified previously with rare incidence. However, the association between COVID-19 infection and autoimmune haemolytic anaemia is not fully evaluated.
Highlights
The number of Coronavirus disease-19 (COVID-19) infected patients is rapidly increasing across the world and the underlying pathophysiology of severe COVID-19 remains poorly understood
Case presentation: Here, we present a case of a previously well patient who developed severe cold agglutinin hemolytic anemia during the course of COVID-19 infection
Conclusion: it is an uncommon presentation, clinicians need to be aware of COVID-19 infectionassociated autoimmune manifestations including warm and cold type haemolytic anaemia
Summary
It is an uncommon presentation, clinicians need to be aware of COVID-19 infectionassociated autoimmune manifestations including warm and cold type haemolytic anaemia. This case emphasizes the importance of an extensive diagnostic workup to identify autoimmune haemolytic anaemia in COVID-19 patients who could present with severe anaemia which requires timely management to save their lives. SARS-CoV-2: Severe Acute Respiratory Syndrome Coronavirus-2; AIHA: Auto Immune Hemolytic Anaemia; RT-PCR: Real-time Reverse Transcription Polymerase. Chain Reaction; Hb: Haemoglobin; MCV: Mean Corpuscular Volume; LDH: Lactate Dehydrogenase; CRP: C-Reactive Protein; ECG: Electrocardiogram; IgG: Immunoglobulin G; IgM: Immunoglobulin M; EBV: Ebstein-Barr Virus; CMV: Cytomegalovirus; HIV: Human Immunodeficiency Virus; ANA: Anti-Nuclear Antibody, USS: Ultra Sound Scan; AKI: Acute Kidney Injury; HTLV-1: Human T-cell Lymphotropic Virus
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