Abstract
Previous studies have reported the comorbidity of arachnoid cysts with psychosis; the symptoms include cognitive impairments, delusional thoughts, and hallucinations. However, the incidence of arachnoid cysts with the sudden onset of severe schizophrenia is rare. This paper describes the case of a 39-year-old Korean man with schizophrenia, who presented with a large arachnoid cyst in the left Sylvian fissure and clozapine-resistant psychosis.
Highlights
Arachnoid cysts are benign, thin-walled cavities filled with cerebrospinal fluid that arise along the craniospinal axis
We present a case of clozapine-resistant schizophrenia associated with a large arachnoid cyst in the left Sylvian fissure
Previous cases of arachnoid cysts in the left temporal lobe comorbid with psychotic disorders typically presented with cognitive deficits, aggression, and atypical psychotic symptoms
Summary
Thin-walled cavities filled with cerebrospinal fluid that arise along the craniospinal axis. Such cysts are quite rare, accounting for only 1% of all lesions occurring in the intracranial space. To the best of our knowledge, comorbid cases of schizophrenia and arachnoid cysts are rare. We present a case of clozapine-resistant schizophrenia associated with a large arachnoid cyst in the left Sylvian fissure. 8-week treatment regimens with high-dose risperidone or clozapine did not effectively attenuate the psychotic symptoms. The patient and his family provided informed consent for publication
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